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Buy Generic AndroGel Online (Testosterone Gel) 1 % |


US Brand: Androgel, Androfil, Testim
Indian (Generic) Brand: Cernos Gel
Manufacturing: Sun Pharmaceutical
Active Substance: Testosterone Gel
Dosage: 1%
Form release: Sachets 5 gramm

(each gramm contain 10 mg of testosterone gel)
Order: Through enquiry form.
Shipping time: 9 – 24 days








US Brand: Androgel, Androfil, Testim
Indian (Generic) Brand: Euphoria Intense
Manufacturing: Health Biotech Ltd.
Active Substance: Testosterone Gel
Dosage: 1%
Form release: Sachets 5 gramm

(each gramm contain 10 mg of testosterone gel)
Order: Through enquiry form.
Shipping time: 9 – 24 days










Description

Pharmacological action

Androgenic. Endogenous androgens (mainly testosterone) secreted by the testes and their main metabolite dihydrotestosterone responsible for the development of external and internal sex organs and for the development and conservation of secondary sexual characteristics (hair growth stimulation, deepening of the voice), libido. Have a general effect on protein anabolism, on the development of the skeletal muscles and the distribution of subcutaneous fat, reduce urinary excretion of nitrogen, sodium, potassium, chloride, phosphate and water. Testosterone does not cause testicular development: it reduces the secretion of pituitary gonadotropins.

Effects of testosterone on some target organs appear after peripheral conversion of testosterone to estradiol, which then binds to the estrogen receptor in the nuclei of target cells (such as the pituitary, adipose tissue, brain, bone, etc.).

Pharmacokinetics

Absorption

Absorption rate of testosterone through the skin varies from about 9% to 14% of the applied dose.

Distribution

After absorption of testosterone into systemic circulation flows in relatively constant concentrations for 24 hours. The concentration of testosterone in serum is increased from the first hour after treatment Androgel, reaching a constant value to the second day of treatment. Daily fluctuations in testosterone concentrations have the same amplitude as observed in the circadian rhythm changes in the content of endogenous testosterone.

For external route of administration are no peaks supraphysiological concentrations of testosterone in the blood resulting from the injection method of application. In contrast to oral androgen therapy, topical application of the drug did not cause an increase in the concentrations of steroids in the liver above the physiological norm. 5 g of AndroGel application causes an average increase in the plasma concentration of testosterone of about 2.5 ng / ml (8.7 nmol / L).

Metabolism

The major active metabolites of testosterone are dihydrotestosterone and estradiol.

Breeding

After discontinuation testosterone concentration begins to decline after about 24 hours after the last application. Concentration returns to baseline approximately 72-96 hours after administration of the last dose. Drug is excreted mainly in the urine and faeces in the form of conjugated metabolites of testosterone.

Dosage

The recommended daily dose is 5 g of gel (ie 50 mg of testosterone). The drug is used 1 time / day at about the same time of day, preferably in the morning. The daily dose may be adjusted depending on the clinical and laboratory parameters, but should not exceed 10 g of gel. Correction mode should be performed in steps of 2.5 g of gel / day.

For correction of the dose necessary to determine the concentration of testosterone in serum in the morning before application of the drug from the third day after treatment (within one week). The dose may be reduced if the content of testosterone in plasma increased or conversely increase when the concentration of low testosterone.

Terms of use of the drug

The gel is applied to clean, dry, intact skin shoulders, arms and / or abdomen. Do not apply the gel to the genital area, because high content of ethanol in the formulation may cause local irritation.

After opening the bag should be immediately put on your skin and all of its contents spread a thin layer. Not necessarily rub it into the skin. Can be allowed to dry for at least 3-5 minutes before dressing. After applying should wash their hands with soap and water.


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